| ชื่อเรื่อง | : | Two selective novel triterpene glycosides from sea cucumber, Telenata ananas: Inhibitors of chemokine receptor-5 |
| นักวิจัย | : | Hegde, V.R. , Chan, T.-M. , Pu, H. , Gullo, V.P. , Patel, M.G. , Das, P. , Wagner, N. , Parameswaran, P.S. , Naik, C.G. |
| คำค้น | : | chemical extraction , glycosides , bioactive compounds , chemoreception , inhibitors , Telenata ananas |
| หน่วยงาน | : | National Institute Of Oceanography (NIO), India |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2545 |
| อ้างอิง | : | Bioorganic Medicinal Chemistry Letters,: Vol. 12; 3203-3205p. , http://drs.nio.org/drs/handle/2264/1344 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | - |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | The aqueous methanolic extract of a sea cucumber was found to contain two triterpene glycosides 1 and 2. The structures of 1 and 2 were established based on high-resolution NMR studies. Compounds 1 and 2 exhibited inhibitory activity (K sub(i)) of 30 and 5 mu M, respectively, in a chemokine receptor subtype 5 (CCR5) assay. Both compounds did not show any significant inhibition in a CXCR2 assay at 50 mu M, suggesting their selectivity for the CCR5 receptor |
| บรรณานุกรม | : |
Hegde, V.R. , Chan, T.-M. , Pu, H. , Gullo, V.P. , Patel, M.G. , Das, P. , Wagner, N. , Parameswaran, P.S. , Naik, C.G. . (2545). Two selective novel triterpene glycosides from sea cucumber, Telenata ananas: Inhibitors of chemokine receptor-5.
: National Institute Of Oceanography (NIO), India. Hegde, V.R. , Chan, T.-M. , Pu, H. , Gullo, V.P. , Patel, M.G. , Das, P. , Wagner, N. , Parameswaran, P.S. , Naik, C.G. . 2545. "Two selective novel triterpene glycosides from sea cucumber, Telenata ananas: Inhibitors of chemokine receptor-5".
: National Institute Of Oceanography (NIO), India. Hegde, V.R. , Chan, T.-M. , Pu, H. , Gullo, V.P. , Patel, M.G. , Das, P. , Wagner, N. , Parameswaran, P.S. , Naik, C.G. . "Two selective novel triterpene glycosides from sea cucumber, Telenata ananas: Inhibitors of chemokine receptor-5."
: National Institute Of Oceanography (NIO), India, 2545. Print. Hegde, V.R. , Chan, T.-M. , Pu, H. , Gullo, V.P. , Patel, M.G. , Das, P. , Wagner, N. , Parameswaran, P.S. , Naik, C.G. . Two selective novel triterpene glycosides from sea cucumber, Telenata ananas: Inhibitors of chemokine receptor-5. : National Institute Of Oceanography (NIO), India; 2545.
|
ridm@nrct.go.th ระบบคลังข้อมูลงานวิจัยไทย รายการโปรดที่คุณเลือกไว้
