| ชื่อเรื่อง | : | An Expedient Synthesis, Acetylcholinesterase Inhibitory Activity, and Molecular Modeling Study of Highly Functionalized Hexahydro-1,6-naphthyridines |
| นักวิจัย | : | Almansour, Abdulrahman I. , Kumar, Raju Suresh , Arumugam, Natarajan , Basiri, Alireza , Kia, Yalda , Ali, Mohamed Ashraf |
| คำค้น | : | QD1-999 Chemistry , RS1-441 Pharmacy and materia medica |
| หน่วยงาน | : | Universiti Sains Malaysia, Malaysia |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2558 |
| อ้างอิง | : | http://eprints.usm.my/38309/1/An_Expedient_Synthesis%2C_Acetylcholinesterase_Inhibitory_Activity%2C_and_Molecular.pdf , Almansour, Abdulrahman I. and Kumar, Raju Suresh and Arumugam, Natarajan and Basiri, Alireza and Kia, Yalda and Ali, Mohamed Ashraf (2015) An Expedient Synthesis, Acetylcholinesterase Inhibitory Activity, and Molecular Modeling Study of Highly Functionalized Hexahydro-1,6-naphthyridines. BioMed Research International, 2015 (965987). pp. 1-9. ISSN 2314-6133 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | http://dx.doi.org/10.1155/2015/965987 , http://eprints.usm.my/38309/ |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | A series of hexahydro-1,6-naphthyridines were synthesized in good yields by the reaction of 3,5-bis[(E)-arylmethylidene] tetrahydro-4(1H)-pyridinones with cyanoacetamide in the presence of sodium ethoxide under simple mixing at ambient temperature for 6–10 minutes and were assayed for their acetylcholinesterase (AChE) inhibitory activity using colorimetric Ellman’s method. Compound 4e with methoxy substituent at ortho-position of the phenyl rings displayed the maximum inhibitory activity with IC50 value of 2.12 |
| บรรณานุกรม | : |
Almansour, Abdulrahman I. , Kumar, Raju Suresh , Arumugam, Natarajan , Basiri, Alireza , Kia, Yalda , Ali, Mohamed Ashraf . (2558). An Expedient Synthesis, Acetylcholinesterase
Inhibitory Activity, and Molecular Modeling Study of Highly
Functionalized Hexahydro-1,6-naphthyridines.
กรุงเทพมหานคร : Universiti Sains Malaysia, Malaysia. Almansour, Abdulrahman I. , Kumar, Raju Suresh , Arumugam, Natarajan , Basiri, Alireza , Kia, Yalda , Ali, Mohamed Ashraf . 2558. "An Expedient Synthesis, Acetylcholinesterase
Inhibitory Activity, and Molecular Modeling Study of Highly
Functionalized Hexahydro-1,6-naphthyridines".
กรุงเทพมหานคร : Universiti Sains Malaysia, Malaysia. Almansour, Abdulrahman I. , Kumar, Raju Suresh , Arumugam, Natarajan , Basiri, Alireza , Kia, Yalda , Ali, Mohamed Ashraf . "An Expedient Synthesis, Acetylcholinesterase
Inhibitory Activity, and Molecular Modeling Study of Highly
Functionalized Hexahydro-1,6-naphthyridines."
กรุงเทพมหานคร : Universiti Sains Malaysia, Malaysia, 2558. Print. Almansour, Abdulrahman I. , Kumar, Raju Suresh , Arumugam, Natarajan , Basiri, Alireza , Kia, Yalda , Ali, Mohamed Ashraf . An Expedient Synthesis, Acetylcholinesterase
Inhibitory Activity, and Molecular Modeling Study of Highly
Functionalized Hexahydro-1,6-naphthyridines. กรุงเทพมหานคร : Universiti Sains Malaysia, Malaysia; 2558.
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