| ชื่อเรื่อง | : | A Potential Epigenetic Marker Mediating Serum Folate and Vitamin B12 Levels Contributes to the Risk of Ischemic Stroke |
| นักวิจัย | : | Loo, Keat Wei , Heidi, Sutherland , Au, Anthony , Camilleri, Emily , Haupt, Larisa M. , Siew, Hua Gan , Griffiths, Lyn R. |
| คำค้น | : | R Medicine (General) |
| หน่วยงาน | : | Universiti Sains Malaysia, Malaysia |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2558 |
| อ้างอิง | : | http://eprints.usm.my/38095/1/A_Potential_Epigenetic_Marker_Mediating_Serum_Folate_and_Vitamin_B12_Levels_Contributes_to_the.pdf , Loo, Keat Wei and Heidi, Sutherland and Au, Anthony and Camilleri, Emily and Haupt, Larisa M. and Siew, Hua Gan and Griffiths, Lyn R. (2015) A Potential Epigenetic Marker Mediating Serum Folate and Vitamin B12 Levels Contributes to the Risk of Ischemic Stroke. BioMed Research International, 2015 (167976). pp. 1-4. ISSN 2314-6133 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | http://dx.doi.org/10.1155/2015/167976 , http://eprints.usm.my/38095/ |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | Stroke is a multifactorial disease that may be associated with aberrant DNA methylation profiles. We investigated epigenetic dysregulation for themethylenetetrahydrofolate reductase (MTHFR) gene among ischemic stroke patients. Cases and controls were recruited after obtaining signed written informed consents following a screening process against the inclusion/exclusion criteria. Serum vitamin profiles (folate, vitamin B12, and homocysteine) were determined using immunoassays. Methylation profiles for CpGs A and B in the MTHFR gene were determined using a bisulfite-pyrosequencingmethod.Methylation of MTHFR significantly increased the susceptibility risk for ischemic stroke. In particular, CpG A outperformed CpG B in mediating serum folate and vitamin B12 levels to increase ischemic stroke susceptibility risks by 4.73-fold. However, both CpGs A and B were not associated with serum homocysteine levels or ischemic stroke severity. CpG A is a potential epigenetic marker in mediating serum folate and vitamin B12 to contribute to ischemic stroke. |
| บรรณานุกรม | : |
Loo, Keat Wei , Heidi, Sutherland , Au, Anthony , Camilleri, Emily , Haupt, Larisa M. , Siew, Hua Gan , Griffiths, Lyn R. . (2558). A Potential Epigenetic Marker Mediating Serum Folate and
Vitamin B12 Levels Contributes to the Risk of Ischemic Stroke.
กรุงเทพมหานคร : Universiti Sains Malaysia, Malaysia. Loo, Keat Wei , Heidi, Sutherland , Au, Anthony , Camilleri, Emily , Haupt, Larisa M. , Siew, Hua Gan , Griffiths, Lyn R. . 2558. "A Potential Epigenetic Marker Mediating Serum Folate and
Vitamin B12 Levels Contributes to the Risk of Ischemic Stroke".
กรุงเทพมหานคร : Universiti Sains Malaysia, Malaysia. Loo, Keat Wei , Heidi, Sutherland , Au, Anthony , Camilleri, Emily , Haupt, Larisa M. , Siew, Hua Gan , Griffiths, Lyn R. . "A Potential Epigenetic Marker Mediating Serum Folate and
Vitamin B12 Levels Contributes to the Risk of Ischemic Stroke."
กรุงเทพมหานคร : Universiti Sains Malaysia, Malaysia, 2558. Print. Loo, Keat Wei , Heidi, Sutherland , Au, Anthony , Camilleri, Emily , Haupt, Larisa M. , Siew, Hua Gan , Griffiths, Lyn R. . A Potential Epigenetic Marker Mediating Serum Folate and
Vitamin B12 Levels Contributes to the Risk of Ischemic Stroke. กรุงเทพมหานคร : Universiti Sains Malaysia, Malaysia; 2558.
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