| ชื่อเรื่อง | : | Prevention of HIV-1 infection with early antiretroviral therapy |
| นักวิจัย | : | Cohen M. , Chen Y. , McCauley M. , Gamble T. , Hosseinipour M. , Kumarasamy N. , Hakim J. , Kumwenda J. , Grinsztejn B. , Pilotto J. , Godbole S. , Mehendale S. , Chariyalertsak S. , Santos B. , Mayer K. , Hoffman I. , Eshleman S. , Piwowar-Manning E. , Wang L. , Makhema J. , Mills L. , De Bruyn G. , Sanne I. , Eron J. , Gallant J. , Havlir D. , Swindells S. , Ribaudo H. , Elharrar V. , Burns D. , Taha T. , Nielsen-Saines K. , Celentano D. , Essex M. , Fleming T. |
| คำค้น | : | - |
| หน่วยงาน | : | มหาวิทยาลัยเชียงใหม่ |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2554 |
| อ้างอิง | : | 00284793 , 2-s2.0-80051633217 , 10.1056/NEJMoa1105243 , https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=80051633217&origin=inward , http://cmuir.cmu.ac.th/jspui/handle/6653943832/43008 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | - |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | BACKGROUND: Antiretroviral therapy that reduces viral replication could limit the transmission of human immunodeficiency virus type 1 (HIV-1) in serodiscordant couples. METHODS: In nine countries, we enrolled 1763 couples in which one partner was HIV-1-positive and the other was HIV-1-negative; 54% of the subjects were from Africa, and 50% of infected partners were men. HIV-1-infected subjects with CD4 counts between 350 and 550 cells per cubic millimeter were randomly assigned in a 1:1 ratio to receive antiretroviral therapy either immediately (early therapy) or after a decline in the CD4 count or the onset of HIV-1-related symptoms (delayed therapy). The primary prevention end point was linked HIV-1 transmission in HIV-1-negative partners. The primary clinical end point was the earliest occurrence of pulmonary tuberculosis, severe bacterial infection, a World Health Organization stage 4 event, or death. RESULTS: As of February 21, 2011, a total of 39 HIV-1 transmissions were observed (incidence rate, 1.2 per 100 person-years; 95% confidence interval [CI], 0.9 to 1.7); of these, 28 were virologically linked to the infected partner (incidence rate, 0.9 per 100 person-years, 95% CI, 0.6 to 1.3). Of the 28 linked transmissions, only 1 occurred in the earlytherapy group (hazard ratio, 0.04; 95% CI, 0.01 to 0.27; P < 0.001). Subjects receiving early therapy had fewer treatment end points (hazard ratio, 0.59; 95% CI, 0.40 to 0.88; P = 0.01). CONCLUSIONS: The early initiation of antiretroviral therapy reduced rates of sexual transmission of HIV-1 and clinical events, indicating both personal and public health benefits from such therapy. (Funded by the National Institute of Allergy and Infectious Diseases and others; HPTN 052 ClinicalTrials.gov number, NCT00074581.) Copyright © 2011 Massachusetts Medical Society. |
| บรรณานุกรม | : |
Cohen M. , Chen Y. , McCauley M. , Gamble T. , Hosseinipour M. , Kumarasamy N. , Hakim J. , Kumwenda J. , Grinsztejn B. , Pilotto J. , Godbole S. , Mehendale S. , Chariyalertsak S. , Santos B. , Mayer K. , Hoffman I. , Eshleman S. , Piwowar-Manning E. , Wang L. , Makhema J. , Mills L. , De Bruyn G. , Sanne I. , Eron J. , Gallant J. , Havlir D. , Swindells S. , Ribaudo H. , Elharrar V. , Burns D. , Taha T. , Nielsen-Saines K. , Celentano D. , Essex M. , Fleming T. . (2554). Prevention of HIV-1 infection with early antiretroviral therapy.
เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ . Cohen M. , Chen Y. , McCauley M. , Gamble T. , Hosseinipour M. , Kumarasamy N. , Hakim J. , Kumwenda J. , Grinsztejn B. , Pilotto J. , Godbole S. , Mehendale S. , Chariyalertsak S. , Santos B. , Mayer K. , Hoffman I. , Eshleman S. , Piwowar-Manning E. , Wang L. , Makhema J. , Mills L. , De Bruyn G. , Sanne I. , Eron J. , Gallant J. , Havlir D. , Swindells S. , Ribaudo H. , Elharrar V. , Burns D. , Taha T. , Nielsen-Saines K. , Celentano D. , Essex M. , Fleming T. . 2554. "Prevention of HIV-1 infection with early antiretroviral therapy".
เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ . Cohen M. , Chen Y. , McCauley M. , Gamble T. , Hosseinipour M. , Kumarasamy N. , Hakim J. , Kumwenda J. , Grinsztejn B. , Pilotto J. , Godbole S. , Mehendale S. , Chariyalertsak S. , Santos B. , Mayer K. , Hoffman I. , Eshleman S. , Piwowar-Manning E. , Wang L. , Makhema J. , Mills L. , De Bruyn G. , Sanne I. , Eron J. , Gallant J. , Havlir D. , Swindells S. , Ribaudo H. , Elharrar V. , Burns D. , Taha T. , Nielsen-Saines K. , Celentano D. , Essex M. , Fleming T. . "Prevention of HIV-1 infection with early antiretroviral therapy."
เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ , 2554. Print. Cohen M. , Chen Y. , McCauley M. , Gamble T. , Hosseinipour M. , Kumarasamy N. , Hakim J. , Kumwenda J. , Grinsztejn B. , Pilotto J. , Godbole S. , Mehendale S. , Chariyalertsak S. , Santos B. , Mayer K. , Hoffman I. , Eshleman S. , Piwowar-Manning E. , Wang L. , Makhema J. , Mills L. , De Bruyn G. , Sanne I. , Eron J. , Gallant J. , Havlir D. , Swindells S. , Ribaudo H. , Elharrar V. , Burns D. , Taha T. , Nielsen-Saines K. , Celentano D. , Essex M. , Fleming T. . Prevention of HIV-1 infection with early antiretroviral therapy. เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ ; 2554.
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