| ชื่อเรื่อง | : | Effects of Curcuma spp. on P-glycoprotein function |
| นักวิจัย | : | Ampasavate C. , Sotanaphun U. , Phattanawasin P. , Piyapolrungroj N. |
| คำค้น | : | - |
| หน่วยงาน | : | มหาวิทยาลัยเชียงใหม่ |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2553 |
| อ้างอิง | : | 9447113 , 10.1016/j.phymed.2009.09.004 , 19879740 , PYTOE , http://www.scopus.com/inward/record.url?eid=2-s2.0-77950867304&partnerID=40&md5=88078a4a19638daa7633b80678f91e9b , http://www.ncbi.nlm.nih.gov/pubmed/19879740 , http://cmuir.cmu.ac.th/handle/6653943832/4502 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | - |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | The effects of Curcuma longa (khamin chan) and Curcuma sp. "khamin-oi" (khamin-oi), as well as isolated major curcuminoids on intestinal P-gp functions were evaluated in vitro. The accumulation of R123 in Caco-2 cells was increased and the R123 efflux ratios were significantly decreased by both Curcuma longa and Curcuma sp. "khamin-oi" extracts, indicating their roles on efflux transporters. The a-b transport of daunorubicin was increased by curcumin, demethoxycurcumin and bisdemethoxycurcumin while the b-a transport was significantly decreased by curcumin and demethoxycurcumin. However, calcein-AM uptake into the human P-gp overexpression cell line, LLC-GA5-COL300, was increased by curcumin and demethoxycurcumin in a concentration-dependent manner but not affected by bisdemethoxycurcumin. These results show that curcumin and demethoxycurcumin could inhibit P-gp but bisdemethoxycurcumin may modulate the function of other efflux transporters such as MRP. Taken together, the information may indicate the impact of Curcuma longa and Curcuma sp. "khamin-oi" on pharmacokinetics of orally administered drugs that are P-gp substrates. © 2009 Elsevier GmbH. All rights reserved. |
| บรรณานุกรม | : |
Ampasavate C. , Sotanaphun U. , Phattanawasin P. , Piyapolrungroj N. . (2553). Effects of Curcuma spp. on P-glycoprotein function.
เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ . Ampasavate C. , Sotanaphun U. , Phattanawasin P. , Piyapolrungroj N. . 2553. "Effects of Curcuma spp. on P-glycoprotein function".
เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ . Ampasavate C. , Sotanaphun U. , Phattanawasin P. , Piyapolrungroj N. . "Effects of Curcuma spp. on P-glycoprotein function."
เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ , 2553. Print. Ampasavate C. , Sotanaphun U. , Phattanawasin P. , Piyapolrungroj N. . Effects of Curcuma spp. on P-glycoprotein function. เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ ; 2553.
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