| ชื่อเรื่อง | : | Production of monoclonal antibodies to P-glycoprotein: Its application in detection of soluble and surface P-glycoprotein of leukemia patients |
| นักวิจัย | : | Chiampanichayakul S. , Anuchapreeda S. , Chruewkamlow N. , Mahasongkram K. , Thanaratanakorn P. , Kasinrerk W. |
| คำค้น | : | - |
| หน่วยงาน | : | มหาวิทยาลัยเชียงใหม่ |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2553 |
| อ้างอิง | : | 9255710 , 10.1007/s12185-010-0668-8 , 20740331 , IJHEE , http://www.scopus.com/inward/record.url?eid=2-s2.0-77956896273&partnerID=40&md5=7a0918b59903cbbded5b676b0e358f15 , http://www.ncbi.nlm.nih.gov/pubmed/20740331 , http://cmuir.cmu.ac.th/handle/6653943832/2545 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | - |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | Multidrug resistance (MDR) in leukemia is commonly associated with the expression of a transmembrane protein, P-glycoprotein (P-gp). In this study, two monoclonal antibodies (mAbs) specific for the extracellular domain of P-gp were generated. By employing the generated mAbs, a two-color lysed whole blood flow cytometric method for surface P-gp and an efficient sandwich ELISA for soluble P-gp determinations were established. By using the established methods, surface and soluble P-gp were detected in several leukemia patients. The presence of soluble P-gp could be used to identify the P-gp surface expression patients. Detection of soluble P-gp reported provides a new basis that may lead to a better understanding of the MDR mechanism in leukemia. © 2010 The Japanese Society of Hematology. |
| บรรณานุกรม | : |
Chiampanichayakul S. , Anuchapreeda S. , Chruewkamlow N. , Mahasongkram K. , Thanaratanakorn P. , Kasinrerk W. . (2553). Production of monoclonal antibodies to P-glycoprotein: Its application in detection of soluble and surface P-glycoprotein of leukemia patients.
เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ . Chiampanichayakul S. , Anuchapreeda S. , Chruewkamlow N. , Mahasongkram K. , Thanaratanakorn P. , Kasinrerk W. . 2553. "Production of monoclonal antibodies to P-glycoprotein: Its application in detection of soluble and surface P-glycoprotein of leukemia patients".
เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ . Chiampanichayakul S. , Anuchapreeda S. , Chruewkamlow N. , Mahasongkram K. , Thanaratanakorn P. , Kasinrerk W. . "Production of monoclonal antibodies to P-glycoprotein: Its application in detection of soluble and surface P-glycoprotein of leukemia patients."
เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ , 2553. Print. Chiampanichayakul S. , Anuchapreeda S. , Chruewkamlow N. , Mahasongkram K. , Thanaratanakorn P. , Kasinrerk W. . Production of monoclonal antibodies to P-glycoprotein: Its application in detection of soluble and surface P-glycoprotein of leukemia patients. เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ ; 2553.
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