Thesis (M.Sc.)--Chulalongkorn University, 2011

Objective: To evaluate glomerular and tubular function and compare prevalence of renal dysfunction between cyanotic and acyanotic congenital heart disease in children and adolescent. Study design: cross-sectional analytic study Setting: Vajira hospital, Pramongktklao hospital, Ramathibodi hospital Research methodology: Blood 3 cc was collected from eligible patients both cyanotic and acyanotic congenital heart disease to evaluated for CBC, electrolyte, BUN, creatinine, magnesium. Urine was collected to evaluated for Urine NAG, creatinine, sodium, magnesium, protein, Microalbumin Results: Forty-six patients, 15 cyanotic and 31 acyanotic congenital heart disease (CHD) were studied. Statistical significant different regarding to systolic blood pressure, hemoglobin, oxygen saturation, cardiac surgery and functional class found between 2 groups. Prevalence of tubular dysfunction and glomerular dysfunction in cyanotic was significantly higher than acyanotic CHD. Conclusion: The prevalence of glomerular and tubular dysfunction in cyanotic congenital heart was higher than acyanotic congenital heart disease. The screening of both glomerular and tubular function is useful to early detect abnormality of glomerular and tubular function in both cyanotic and acyanotic congenital heart disease.