| ชื่อเรื่อง | : | Structure of a left-handed DNA G-quadruplex |
| นักวิจัย | : | Chung, Wan Jun , Heddi, Brahim , Schmitt, Emmanuelle , Lim, Kah Wai , Mechulam, Yves , Phan, Anh Tuân |
| คำค้น | : | DRNTU::Science::Biological sciences::Molecular biology |
| หน่วยงาน | : | Nanyang Technological University, Singapore |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2558 |
| อ้างอิง | : | Chung, W. J., Heddi, B., Schmitt, E., Lim, K. W., Mechulam, Y., & Phan, A. T. (2015). Structure of a left-handed DNA G-quadruplex. Proceedings of the National Academy of Sciences, 112(9), 2729-2733. , http://hdl.handle.net/10220/25356 , http://dx.doi.org/10.1073/pnas.1418718112 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | Proceedings of the National Academy of Sciences |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | Aside from the well-known double helix, DNA can also adopt an alternative four-stranded structure known as G-quadruplex. Implications of such a structure in cellular processes, as well as its therapeutic and diagnostic applications, have been reported. The G-quadruplex structure is highly polymorphic, but so far, only right-handed helical forms have been observed. Here we present the NMR solution and X-ray crystal structures of a left-handed DNA G-quadruplex. The structure displays unprecedented features that can be exploited as unique recognition elements. |
| บรรณานุกรม | : |
Chung, Wan Jun , Heddi, Brahim , Schmitt, Emmanuelle , Lim, Kah Wai , Mechulam, Yves , Phan, Anh Tuân . (2558). Structure of a left-handed DNA G-quadruplex.
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Chung, Wan Jun , Heddi, Brahim , Schmitt, Emmanuelle , Lim, Kah Wai , Mechulam, Yves , Phan, Anh Tuân . 2558. "Structure of a left-handed DNA G-quadruplex".
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Chung, Wan Jun , Heddi, Brahim , Schmitt, Emmanuelle , Lim, Kah Wai , Mechulam, Yves , Phan, Anh Tuân . "Structure of a left-handed DNA G-quadruplex."
กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2558. Print. Chung, Wan Jun , Heddi, Brahim , Schmitt, Emmanuelle , Lim, Kah Wai , Mechulam, Yves , Phan, Anh Tuân . Structure of a left-handed DNA G-quadruplex. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2558.
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