In order to successfully connect the whole supply chain, an information standard is needed to exchange electronic documents between business partners. XML-based standard are starting to gain popularity over EDI-based standard in many industries. There are two main standards being implemented by the industry. ebXML is supported by the United Nations and OASIS while RosettaNet is supported by companies in electronics and high-tech industry. The aim of these standards is to electronically connect companies within the same supply chain, regardless of their sizes. In this research, we study a medium size multinational pharmaceutical company in Thailand, and how a web-based system and a business standard for information flow (RosettaNet standard in this case) can be applied to improve efficiency in its supply chain. In particular, we examine the information flow during the process of order transactions between the pharmaceutical company, its customers (hospitals), and its distributors. We first examine the current business process and propose a new process with a web-based system. The new system is examined and ROI model is analyzed.