| ชื่อเรื่อง | : | Insights into the role of focal adhesion modulation in myogenic differentiation of human mesenchymal stem cells |
| นักวิจัย | : | Yu, Haiyang , Lui, Yuan Siang , Xiong, Sijing , Leong, Wen Shing , Wen, Feng , Nurkahfianto, Himawan , Rana, Sravendra , Leong, David Tai , Ng, Kee Woei , Tan, Lay Poh |
| คำค้น | : | DRNTU::Engineering::Materials::Biomaterials |
| หน่วยงาน | : | Nanyang Technological University, Singapore |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2556 |
| อ้างอิง | : | Yu, H., Lui, Y. S., Xiong, S., Leong, W. S., Wen, F., Nurkahfianto, H., et al. (2013). Insights into the role of focal adhesion modulation in myogenic differentiation of human mesenchymal stem cells. Stem cells and development, 22(1), 136-147. , 1547-3287 , http://hdl.handle.net/10220/23990 , http://dx.doi.org/10.1089/scd.2012.0160 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | Stem cells and development |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | We report the establishment of a novel platform to induce myogenic differentiation of human mesenchymal stem cells (hMSCs) via focal adhesion (FA) modulation, giving insights into the role of FA on stem cell differentiation. Micropatterning of collagen type I on a polyacrylamide gel with a stiffness of 10.2 kPa efficiently modulated elongated FA. This elongated FA profile preferentially recruited the β3 integrin cluster and induced specific myogenic differentiation at both transcription and translation levels with expression of myosin heavy chain and α-sarcomeric actin. This was initiated with elongation of FA complexes that triggered the RhoA downstream signaling toward a myogenic lineage commitment. This study also illustrates how one could partially control myogenic differentiation outcomes of similar-shaped hMSCs by modulating FA morphology and distribution. This technology increases our toolkit choice for controlled differentiation in muscle engineering. |
| บรรณานุกรม | : |
Yu, Haiyang , Lui, Yuan Siang , Xiong, Sijing , Leong, Wen Shing , Wen, Feng , Nurkahfianto, Himawan , Rana, Sravendra , Leong, David Tai , Ng, Kee Woei , Tan, Lay Poh . (2556). Insights into the role of focal adhesion modulation in myogenic differentiation of human mesenchymal stem cells.
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Yu, Haiyang , Lui, Yuan Siang , Xiong, Sijing , Leong, Wen Shing , Wen, Feng , Nurkahfianto, Himawan , Rana, Sravendra , Leong, David Tai , Ng, Kee Woei , Tan, Lay Poh . 2556. "Insights into the role of focal adhesion modulation in myogenic differentiation of human mesenchymal stem cells".
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Yu, Haiyang , Lui, Yuan Siang , Xiong, Sijing , Leong, Wen Shing , Wen, Feng , Nurkahfianto, Himawan , Rana, Sravendra , Leong, David Tai , Ng, Kee Woei , Tan, Lay Poh . "Insights into the role of focal adhesion modulation in myogenic differentiation of human mesenchymal stem cells."
กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2556. Print. Yu, Haiyang , Lui, Yuan Siang , Xiong, Sijing , Leong, Wen Shing , Wen, Feng , Nurkahfianto, Himawan , Rana, Sravendra , Leong, David Tai , Ng, Kee Woei , Tan, Lay Poh . Insights into the role of focal adhesion modulation in myogenic differentiation of human mesenchymal stem cells. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2556.
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