| ชื่อเรื่อง | : | Biophysical and structural studies of self-assembled liposome/e-peptide/dna nanoparticles : correlation with gene delivery. |
| นักวิจัย | : | Yan, Jiang. |
| คำค้น | : | DRNTU::Science::Biological sciences. |
| หน่วยงาน | : | Nanyang Technological University, Singapore |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2555 |
| อ้างอิง | : | Yan, J. (2012). Biophysical and structural studies of self-assembled liposome/e-peptide/dna nanoparticles : correlation with gene delivery. Doctoral thesis, Nanyang Technological University, Singapore. , http://hdl.handle.net/10356/50471 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | - |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | Recently, novel DNA compaction agents, ε-oligo(L-lysines) and their branched α-amino-acid substituted derivatives, have been successfully tested as vectors for in vitro gene delivery. The present work exploits a number of newly developed ε-oligolysine-based peptides: ε-(LYRH)K10, ε-(LYH)K10, ε-(LYK)K10, ε-(LKY)K10 and ε-(YKL)K10. ε-oligolysine backbone was synthesized with degree of polymerization 10 and α-amino acid triplets (amino acids in the brackets) were attached to each of the α-amino group of ε-oligolysine (Fig. 1). Since it was found that combined effect of lipids and polycations can greatly enhance transfection efficiency, our novel ε-peptides were used in the combination of cationic liposome DOTAP (1,2-dioleoyl-3-trimethylammonium-propane), resulting in a ternary complex liposome/ε-peptides/DNA (LPD). |
| บรรณานุกรม | : |
Yan, Jiang. . (2555). Biophysical and structural studies of self-assembled liposome/e-peptide/dna nanoparticles : correlation with gene delivery..
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Yan, Jiang. . 2555. "Biophysical and structural studies of self-assembled liposome/e-peptide/dna nanoparticles : correlation with gene delivery.".
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Yan, Jiang. . "Biophysical and structural studies of self-assembled liposome/e-peptide/dna nanoparticles : correlation with gene delivery.."
กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print. Yan, Jiang. . Biophysical and structural studies of self-assembled liposome/e-peptide/dna nanoparticles : correlation with gene delivery.. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.
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