| ชื่อเรื่อง | : | Silica Gel-Mediated Hydroamination/Semipinacol Rearrangement of 2-Alkylaminophenylprop-1-yn-3-ols: Synthesis of 2-Oxindoles from Alkynes and 1-(2-Aminophenyl) Ketones |
| นักวิจัย | : | Susanti, Dewi , Ng, Linda Li Ru , Chan, Philip Wai Hong |
| คำค้น | : | - |
| หน่วยงาน | : | Nanyang Technological University, Singapore |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2557 |
| อ้างอิง | : | Susanti, D., Ng, L. L. R., & Chan, P. W. H. (2014). Silica Gel-Mediated Hydroamination/Semipinacol Rearrangement of 2-Alkylaminophenylprop-1-yn-3-ols: Synthesis of 2-Oxindoles from Alkynes and 1-(2-Aminophenyl) Ketones. Advanced Synthesis & Catalysis, 356(2-3), 353-358. , 1615-4150 , http://hdl.handle.net/10220/19716 , http://dx.doi.org/10.1002/adsc.201300911 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | Advanced synthesis & catalysis |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | 2-Alkylaminophenylprop-1-yn-3-ols, prepared from the lithium diisopropylamide (LDA)-mediated 1,2-addition of alkynes to 1-(2-aminophenyl) ketones, can be converted to 3,3-disubstituted 2-oxindoles by using silica gel in n-hexane/ethyl acetate (20:1 v/v) as the reaction medium. The utility of the approach as a potential scale-up strategy for the synthesis of 2-oxindoles was exemplified by the large-scale synthesis of one adduct in excellent yield. The synthetic applicability of this chemistry was also demonstrated by the recycling of the silica gel up to 8 times with no apparent loss of activity being observed for the same example. |
| บรรณานุกรม | : |
Susanti, Dewi , Ng, Linda Li Ru , Chan, Philip Wai Hong . (2557). Silica Gel-Mediated Hydroamination/Semipinacol Rearrangement of 2-Alkylaminophenylprop-1-yn-3-ols: Synthesis of 2-Oxindoles from Alkynes and 1-(2-Aminophenyl) Ketones.
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Susanti, Dewi , Ng, Linda Li Ru , Chan, Philip Wai Hong . 2557. "Silica Gel-Mediated Hydroamination/Semipinacol Rearrangement of 2-Alkylaminophenylprop-1-yn-3-ols: Synthesis of 2-Oxindoles from Alkynes and 1-(2-Aminophenyl) Ketones".
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Susanti, Dewi , Ng, Linda Li Ru , Chan, Philip Wai Hong . "Silica Gel-Mediated Hydroamination/Semipinacol Rearrangement of 2-Alkylaminophenylprop-1-yn-3-ols: Synthesis of 2-Oxindoles from Alkynes and 1-(2-Aminophenyl) Ketones."
กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2557. Print. Susanti, Dewi , Ng, Linda Li Ru , Chan, Philip Wai Hong . Silica Gel-Mediated Hydroamination/Semipinacol Rearrangement of 2-Alkylaminophenylprop-1-yn-3-ols: Synthesis of 2-Oxindoles from Alkynes and 1-(2-Aminophenyl) Ketones. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2557.
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