| ชื่อเรื่อง | : | Discovery of a natural product-like iNOS inhibitor by molecular docking with potential neuroprotective effects in vivo |
| นักวิจัย | : | Zhong, Hai-Jing , Liu, Li-Juan , Chong, Cheong-Meng , Lu, Lihua , Wang, Modi , Chan, Daniel Shiu-Hin , Chan, Philip Wai Hong , Lee, Simon Ming-Yuen , Ma, Dik-Lung , Leung, Chung-Hang |
| คำค้น | : | DRNTU::Science |
| หน่วยงาน | : | Nanyang Technological University, Singapore |
| ผู้ร่วมงาน | : | Verma, Chandra |
| ปีพิมพ์ | : | 2557 |
| อ้างอิง | : | Zhong, H.-J., Liu, L.-J., Chong, C.-M., Lu, L., Wang, M., Chan, D. S.-H., et al. (2014). Discovery of a Natural Product-Like iNOS Inhibitor by Molecular Docking with Potential Neuroprotective Effects In Vivo. PLoS ONE, 9(4), e92905-. , 1932-6203 , http://hdl.handle.net/10220/19561 , http://dx.doi.org/10.1371/journal.pone.0092905 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | PLoS ONE |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | In this study, we applied structure-based virtual screening techniques to identify natural product or natural product-like inhibitors of iNOS. The iNOS inhibitory activity of the hit compounds was characterized using cellular assays and an in vivo zebrafish larvae model. The natural product-like compound 1 inhibited NO production in LPS-stimulated Raw264.7 macrophages, without exerting cytotoxic effects on the cells. Significantly, compound 1 was able to reverse MPTP-induced locomotion deficiency and neurotoxicity in an in vivo zebrafish larval model. Hence, compound 1 could be considered as a scaffold for the further development of iNOS inhibitors for potential anti-inflammatory or anti-neurodegenerative applications. |
| บรรณานุกรม | : |
Zhong, Hai-Jing , Liu, Li-Juan , Chong, Cheong-Meng , Lu, Lihua , Wang, Modi , Chan, Daniel Shiu-Hin , Chan, Philip Wai Hong , Lee, Simon Ming-Yuen , Ma, Dik-Lung , Leung, Chung-Hang . (2557). Discovery of a natural product-like iNOS inhibitor by molecular docking with potential neuroprotective effects in vivo.
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Zhong, Hai-Jing , Liu, Li-Juan , Chong, Cheong-Meng , Lu, Lihua , Wang, Modi , Chan, Daniel Shiu-Hin , Chan, Philip Wai Hong , Lee, Simon Ming-Yuen , Ma, Dik-Lung , Leung, Chung-Hang . 2557. "Discovery of a natural product-like iNOS inhibitor by molecular docking with potential neuroprotective effects in vivo".
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Zhong, Hai-Jing , Liu, Li-Juan , Chong, Cheong-Meng , Lu, Lihua , Wang, Modi , Chan, Daniel Shiu-Hin , Chan, Philip Wai Hong , Lee, Simon Ming-Yuen , Ma, Dik-Lung , Leung, Chung-Hang . "Discovery of a natural product-like iNOS inhibitor by molecular docking with potential neuroprotective effects in vivo."
กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2557. Print. Zhong, Hai-Jing , Liu, Li-Juan , Chong, Cheong-Meng , Lu, Lihua , Wang, Modi , Chan, Daniel Shiu-Hin , Chan, Philip Wai Hong , Lee, Simon Ming-Yuen , Ma, Dik-Lung , Leung, Chung-Hang . Discovery of a natural product-like iNOS inhibitor by molecular docking with potential neuroprotective effects in vivo. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2557.
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