| ชื่อเรื่อง | : | Organocatalytic asymmetric Mannich reactions of 5H-oxazol-4-ones : highly enantio- and diastereoselective synthesis of chiral α-alkylisoserine derivatives |
| นักวิจัย | : | Han, Zhiqiang , Yang, Wenguo , Tan, Choon-Hong , Jiang, Zhiyong |
| คำค้น | : | DRNTU::Science::Chemistry::Organic chemistry. |
| หน่วยงาน | : | Nanyang Technological University, Singapore |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2556 |
| อ้างอิง | : | Han, Z., Yang, W., Tan, C. H., & Jiang, Z. (2013). Organocatalytic asymmetric Mannich reactions of 5H-oxazol-4-ones : highly enantio- and diastereoselective synthesis of chiral α-alkylisoserine derivatives. Advanced Synthesis & Catalysis, 355(8), 1505-1511. , 1615-4150 , http://hdl.handle.net/10220/19084 , http://dx.doi.org/10.1002/adsc.201300135 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | Advanced synthesis & catalysis |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | The first organocatalytic Mannich reaction of 5H-oxazol-4-ones with various readily prepared aryl- and alkylsulfonimides has been developed. Two commercially available pseudoenantiomeric Cinchona alkaloids-derived tertiary amine/ureas have been demonstrated as the most efficient catalysts to access the opposite enantiomers of the Mannich products with equally excellent enantio- and diastereoselectivities. From the Mannich adducts, important α-methyl-α-hydroxy-β-amino acid derivatives, such as the α-methylated C-13 side chain of taxol and taxotere, can be conveniently prepared. |
| บรรณานุกรม | : |
Han, Zhiqiang , Yang, Wenguo , Tan, Choon-Hong , Jiang, Zhiyong . (2556). Organocatalytic asymmetric Mannich reactions of 5H-oxazol-4-ones : highly enantio- and diastereoselective synthesis of chiral α-alkylisoserine derivatives.
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Han, Zhiqiang , Yang, Wenguo , Tan, Choon-Hong , Jiang, Zhiyong . 2556. "Organocatalytic asymmetric Mannich reactions of 5H-oxazol-4-ones : highly enantio- and diastereoselective synthesis of chiral α-alkylisoserine derivatives".
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Han, Zhiqiang , Yang, Wenguo , Tan, Choon-Hong , Jiang, Zhiyong . "Organocatalytic asymmetric Mannich reactions of 5H-oxazol-4-ones : highly enantio- and diastereoselective synthesis of chiral α-alkylisoserine derivatives."
กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2556. Print. Han, Zhiqiang , Yang, Wenguo , Tan, Choon-Hong , Jiang, Zhiyong . Organocatalytic asymmetric Mannich reactions of 5H-oxazol-4-ones : highly enantio- and diastereoselective synthesis of chiral α-alkylisoserine derivatives. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2556.
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