| ชื่อเรื่อง | : | Bioconjugated pluronic triblock-copolymer Micelle-encapsulated quantum dots for targeted imaging of cancer : in vitro and in vivo studies |
| นักวิจัย | : | Liu, Liwei , Yong, Ken-Tye , Roy, Indrajit , Law, Wing-Cheung , Ye, Ling , Liu, Jianwei , Liu, Jing , Kumar, Rajiv , Zhang, Xihe , Prasad, Paras N. |
| คำค้น | : | DRNTU::Engineering::Electrical and electronic engineering. |
| หน่วยงาน | : | Nanyang Technological University, Singapore |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2555 |
| อ้างอิง | : | Liu, L., Yong, K.-T., Roy, I., Law, W.-C., Ye, L., Liu, J., et al. (2012). Bioconjugated Pluronic Triblock-Copolymer Micelle-Encapsulated Quantum Dots for Targeted Imaging of Cancer: In Vitro and In Vivo Studies. Theranostics, 2(7), 705-713. , 1838-7640 , http://hdl.handle.net/10220/11854 , http://dx.doi.org/10.7150/thno.3456 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | Theranostics |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | Early in this study, CdTe/ZnS core/shell quantum dots (QDs) were encapsulated in carboxylated Pluronic F127 triblock polymeric micelle, to preserve the optical and colloidal stability of QDs in biological fluids. Folic acid (FA) was then conjugated to the surface of QDs for the targeted delivery of the QD formulation to the tumor site, by exploiting the overexpressed FA receptors (FARs) on the tumor cells. Cytotoxicity study demonstrated that the QD formulation has negligible in vitro toxicity. The in vitro study showed that the bioconjugated micelle-encapsulated QDs, but not the unconjugated QDs, were able to efficiently label Panc-1 cancer cells. In vivo imaging study showed that bioconjugated QDs were able to target tumor site after intravenous injection of the formulation in tumor-bearing mice. |
| บรรณานุกรม | : |
Liu, Liwei , Yong, Ken-Tye , Roy, Indrajit , Law, Wing-Cheung , Ye, Ling , Liu, Jianwei , Liu, Jing , Kumar, Rajiv , Zhang, Xihe , Prasad, Paras N. . (2555). Bioconjugated pluronic triblock-copolymer Micelle-encapsulated quantum dots for targeted imaging of cancer : in vitro and in vivo studies.
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Liu, Liwei , Yong, Ken-Tye , Roy, Indrajit , Law, Wing-Cheung , Ye, Ling , Liu, Jianwei , Liu, Jing , Kumar, Rajiv , Zhang, Xihe , Prasad, Paras N. . 2555. "Bioconjugated pluronic triblock-copolymer Micelle-encapsulated quantum dots for targeted imaging of cancer : in vitro and in vivo studies".
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Liu, Liwei , Yong, Ken-Tye , Roy, Indrajit , Law, Wing-Cheung , Ye, Ling , Liu, Jianwei , Liu, Jing , Kumar, Rajiv , Zhang, Xihe , Prasad, Paras N. . "Bioconjugated pluronic triblock-copolymer Micelle-encapsulated quantum dots for targeted imaging of cancer : in vitro and in vivo studies."
กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print. Liu, Liwei , Yong, Ken-Tye , Roy, Indrajit , Law, Wing-Cheung , Ye, Ling , Liu, Jianwei , Liu, Jing , Kumar, Rajiv , Zhang, Xihe , Prasad, Paras N. . Bioconjugated pluronic triblock-copolymer Micelle-encapsulated quantum dots for targeted imaging of cancer : in vitro and in vivo studies. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.
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