The purpose of this research was to study (within a theoretical framework Lazaruss stress Theory and dependent care agency derived from Orems conceptual model of nursing) care burden and general well-being, coping resources of duration of education, problem of medical cost, duration of caregiving, and activities of daily living of elderly to identify predictive factors of general well-being in family caregivers of dependent elderly. Dependent elderly had been admitted in medical department of Ramathibodi Hospital and Saint Louis Hospital and discharged from the hospital for 2 weeks. By mailing, response rate was 62.01X, but completed 55.87%. The final sample consisted 100 family caregivers. Care burden was measured by The Caregiving Burden Scale developed by Oberst (1991). General well-being was measured by The General Well-Being developed by Dupuy (1977). Result of the study showed that subjects reported a low mean score on dependent care burden, thirty - seven percent of the family caregivers reported moderate distress and the same quality of positive well - being, twenty - six percent of them reported severe distress. Care Burden and problem of medical cost, were negative correlated with general well - being, (r = - .40, P < .001

r = - .31, P < .001 respectively), duration of education was positive correlated with general well - being (r = .25, P < .05) When all variables were entered into the stepwise multiple regression model to predict general well - being, only care burden and duration of education were significant predictors and accounted for twenty - one percent of variance in general well - being which was significant. Care burden was the best predictor.