Research on breeding, seed production and culture of groupers at the Southeast Asian Fisheries Development Center Aquaculture Department (SEAFDEC AQD) was initiated following the recommendations of the 1987 Seminar-Workshop on Aquaculture Development in Southeast Asia (ADSEA) which prioritized the department’s research and development activities. Initial activities focused on developing a captive broodstock, conducting a market survey of grouper species in the Philippines and in SE Asia (Kohno 1986; 1987; Kohno and Duray, 1989; Kohno et al. 1990), determining fry availability in reported fry grounds within Panay Island where the department is located, and conducting a survey of culture practices in the Philippines (Kohno et al., 1988). Since the most common grouper species cultured in the Philippines and fished from coastal waters is Epinephelus coiodes (syn. E. suillus), esearch effort was focused on this species. This paper reviews the progress of research and development in breeding, seed production, nursery, and grow out culture of E.coioides at the SEAFDEC Aquaculture Department.