| ชื่อเรื่อง | : | Construction And Evaluation Of Multigene Mutants Of Vibrio Cholerae O139 As Vaccine Candidates |
| นักวิจัย | : | Murugaiah, Chandrika |
| คำค้น | : | R5-920 Medicine (General) |
| หน่วยงาน | : | Universiti Sains Malaysia, Malaysia |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2554 |
| อ้างอิง | : | http://eprints.usm.my/43233/1/CHANDRIKA%20MURUGAIAH.pdf , Murugaiah, Chandrika (2011) Construction And Evaluation Of Multigene Mutants Of Vibrio Cholerae O139 As Vaccine Candidates. PhD thesis, Universiti Sains Malaysia. |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | http://eprints.usm.my/43233/ , http://ezproxy.usm.my/login?url=http ://ethesis.usm.my/jspui |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | Cholera is a major health issue, affecting millions of lives annually. In light of the recurrent outbreaks of cholera, there is a pressing need for the development of vaccines that allow rapid mass vaccination. In this study, genetically modified vaccine candidates, VCUSM21P and VCUSM22P, were designed. VCUSM21P is a prototrophic vaccine which encodes non-toxic cholera toxin A (ctxA) subunit immunogen and has accessory cholera enterotoxin (ace), zonula occludens toxin (zot) and repeats-in-toxin C/A (rtxC/A) mutations. On the other hand, VCUSM22P is ace, zot, ctxA, rtxC/A and haemagglutinin/protease (hap) mutant. Both mutants were found not to disassemble the actin of HEp2 cells. |
| บรรณานุกรม | : |
Murugaiah, Chandrika . (2554). Construction And Evaluation Of Multigene Mutants Of Vibrio Cholerae O139 As Vaccine Candidates.
กรุงเทพมหานคร : Universiti Sains Malaysia, Malaysia. Murugaiah, Chandrika . 2554. "Construction And Evaluation Of Multigene Mutants Of Vibrio Cholerae O139 As Vaccine Candidates".
กรุงเทพมหานคร : Universiti Sains Malaysia, Malaysia. Murugaiah, Chandrika . "Construction And Evaluation Of Multigene Mutants Of Vibrio Cholerae O139 As Vaccine Candidates."
กรุงเทพมหานคร : Universiti Sains Malaysia, Malaysia, 2554. Print. Murugaiah, Chandrika . Construction And Evaluation Of Multigene Mutants Of Vibrio Cholerae O139 As Vaccine Candidates. กรุงเทพมหานคร : Universiti Sains Malaysia, Malaysia; 2554.
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