Molecules of the title compound, C16H16N4O7, are not planar with a dihedral angle of 5.50 (11)� between the substituted benzene rings. The two meta-methoxy groups of the 3,4,5- trimethoxybenzene moiety lie in the plane of the attached ring [Cmethyl–O–C–C torsion angles �0.1 (4)� and �3.7 (3)�] while the para-methoxy substituent lies out of the plane [Cmethyl— O—C—C, �86.0 (3)�]. An intramolecular N—H� � �O hydrogen bond involving the 2-nitro substituent generates an S(6) ring motif. In the crystal structure, molecules are linked by weak C—H� � �O interactions into screw chains, that are arranged into a sheet parallel to the bc plane. These sheets are connected by �–� stacking interactions between the nitro and methoxy substituted aromatic rings with a centroid– centroid separation of 3.9420 (13) A ° . C—H� � �� contacts further stabilize the two-dimensional network.