| ชื่อเรื่อง | : | Expedient Base-Mediated Desulfitative Dimethylamination, Oxidation, or Etherification of 2-(Methylsulfanyl)-3,5-dihydro-4H-imidazol-4-one Scaffolds |
| นักวิจัย | : | Khan, Shahnawaz , Tyagi, Vikas , Mahar, Rohit , Bajpai, Vikas , Kumar, Brijesh , Chauhan, P M S |
| คำค้น | : | Heterocycles , Aminations , Etherifications , Oxidations , Ketones , Amines , Ethers |
| หน่วยงาน | : | Central Drug Research Institute (CDRI), India |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2556 |
| อ้างอิง | : | Synthesis, 2013, 45(17), 2405-2412 , http://hdl.handle.net/123456789/1403 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | CSIR-CDRI Communication No. 8441 |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | The dimethylamino functionality is generally introduced onto the 3,5-dihydro-4H-imidazol-4-one skeleton by treatment of a halogenated derivative with low-boiling dimethylamine at a high temperature and pressure. The corresponding aliphatic ethers are usually prepared by Williamson ether synthesis, but the available transition-metal-catalyzed methods require highly toxic reagents (such as dimethyl sulfate or methyl halides) and expensive metal catalysts, and they entail harsh reaction conditions and complex workups. A simple and efficient method is described for base-mediated¬ desulfitative dimethylamination, oxidation, or etherification at the C2-position of the 2-(methylsulfanyl)-3,5-dihydro-4H-imidazol-4-one scaffold by using potassium carbonate and aqueous N,N-dimethylformamide or an aliphatic alcohol. |
| บรรณานุกรม | : |
Khan, Shahnawaz , Tyagi, Vikas , Mahar, Rohit , Bajpai, Vikas , Kumar, Brijesh , Chauhan, P M S . (2556). Expedient Base-Mediated Desulfitative Dimethylamination, Oxidation, or Etherification of 2-(Methylsulfanyl)-3,5-dihydro-4H-imidazol-4-one Scaffolds.
: Central Drug Research Institute (CDRI), India. Khan, Shahnawaz , Tyagi, Vikas , Mahar, Rohit , Bajpai, Vikas , Kumar, Brijesh , Chauhan, P M S . 2556. "Expedient Base-Mediated Desulfitative Dimethylamination, Oxidation, or Etherification of 2-(Methylsulfanyl)-3,5-dihydro-4H-imidazol-4-one Scaffolds".
: Central Drug Research Institute (CDRI), India. Khan, Shahnawaz , Tyagi, Vikas , Mahar, Rohit , Bajpai, Vikas , Kumar, Brijesh , Chauhan, P M S . "Expedient Base-Mediated Desulfitative Dimethylamination, Oxidation, or Etherification of 2-(Methylsulfanyl)-3,5-dihydro-4H-imidazol-4-one Scaffolds."
: Central Drug Research Institute (CDRI), India, 2556. Print. Khan, Shahnawaz , Tyagi, Vikas , Mahar, Rohit , Bajpai, Vikas , Kumar, Brijesh , Chauhan, P M S . Expedient Base-Mediated Desulfitative Dimethylamination, Oxidation, or Etherification of 2-(Methylsulfanyl)-3,5-dihydro-4H-imidazol-4-one Scaffolds. : Central Drug Research Institute (CDRI), India; 2556.
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