Abstract Purpose. Regular exercise is considered important for long-term health outcomes and fatigue management in persons with multiple sclerosis (MS); however, little is known about the experiences of individuals with MS-related fatigue, who participate in community-based exercise activities. The aim of this study was to describe the experiences of people with MS-related fatigue,who engaged in community-based exercise activities in order to discover how fatigue influenced their exercise participation. Method. In this study, we used qualitative methodology based on the interpretive description approach to collect and analyse data. Individuals with MS, who experienced fatigue and regularly participated in community-based exercise activities, were interviewed. Interviews were audio taped and transcribed verbatim. Data were analysed using an inductive thematic approach with multi-step verification strategies. Results. We found that perceived control over MS-related fatigue influenced exercise choices in our participants. Furthermore, perceived control over fatigue was influenced by seven factors: wellness philosophy, a related goal, belief that control was possible, feeling safe and supported, ability to manage limits, being satisfied with trade-offs and positive definition of self. Conclusion. Identification of factors influencing perceived control over fatigue will assist health care providers when facilitating community exercise choices for people with MS.