Background: This study examines perceived health effect risks from air pollution during the work-related commute by socio-demographic and travel mode variables. Methods: Population-representative survey data were collected by telephone from 745 adults from Queensland, Australia. Variables assessed included socio-demographics, usual work travel mode, commute perceptions, and perceived health effects associated with air pollution during the work-related commute. Results: Approximately 45% of the sample perceived air pollution negatively affected health outcomes when commuting to/from work, yet only 13% recognised air pollution as a major barrier to walking or cycling to/from work. No relationships existed between usual travel mode to/from work and perceived health risks associated with air pollution. Those higher educated or living in major cities were more likely to recognise air pollution harmed their health during their work-related commute when compared to respective referent categories (p< 0.05). Conclusions: Recognition of health risks from air pollution during the work-related commute was high, and awareness did not differ by travel mode. For the majority, air pollution was not a primary barrier for walking or cycling to/from work.