The performance of the hybrid powdered activated carbon (PAC)-submerged membrane system for trace organics treatment from water was studied through both experimental studies and mathematical simulations. The PAC adsorption process optimization was studied by investigating the effects of PAC particle size, continuous/intermittent air bubbling at different bubbling rates and additional factors introduced by air bubbling on the adsorption efficiency through single solute batch adsorption tests on atrazine removal. The adsorption kinetics coefficients (liquid film) and (surface diffusion) were quantified through both a simple approach of film mass transfer and the complex homogeneous surface diffusion model (HSDM) respectively based on the single solute batch test data. Mathematical models have been developed to describe PAC adsorption in both a bubbling mixed single-stage continuous process and a two-stage countercurrent PAC-submerged hollow fiber membrane system under batch and continuous dosing of PAC. The developed models were verified and then used to predict the product water quality at different operation conditions such as different air bubbling rates, carbon dosages and water fluxes. Finally, a preliminary study of novel in-situ regeneration method for saturated PACs in a hybrid submerged membrane system using photocatalytic oxidation (TiO2) was made and confirmed experimentally.