| ชื่อเรื่อง | : | Novel zinc finger motif in the basal transcriptional machinery : three-dimensional NMR studies of the nucleic acid binding domain of transcriptional elongation factor TFIIS |
| นักวิจัย | : | Qian, Xiuqi , Gozani, Shai N. , Yoon, Ho Sup , Jeon, Choon Ju , Agarwal, Kan , Weiss, Michael A. |
| คำค้น | : | DRNTU::Science::Biological sciences::Biochemistry. |
| หน่วยงาน | : | Nanyang Technological University, Singapore |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2536 |
| อ้างอิง | : | Qian, X., Gozani, S. N., Yoon, H., Jeon, C., Agarwal, K., & Weiss, M. A. (1993). Novel zinc finger motif in the basal transcriptional machinery: Three-dimensional NMR studies of the nucleic acid binding domain of transcriptional elongation factor TFIIS. Biochemistry, 32(38), 9944-9959. , http://hdl.handle.net/10220/7481 , http://dx.doi.org/10.1021/bi00089a010 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | Biochemistry |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | Transcriptional elongation provides a key control point in the regulation of eukaryotic gene expression. Here we describe homonuclear and lSN-heteronuclear 3D NMR studies of the nucleic acid binding domain of human transcriptional elongation factor TFIIS. This domain contains a Cys4 ZnZ+- binding site with no homology to previously characterized Cys4, Cysa, or Cysz-His2 Zn fingers. Complete lH and I5N NMR resonance assignment of a 50-residue TFIIS peptideZnz+ complex is obtained. Its solution structure, as determined by distance geometry/simulated annealing (DG/SA) calculations, exhibits a novel three-stranded antiparallel p-sheet (designated the Zn ribbon). Analogous sequence motifs occur in a wide class of proteins involved in RNA or DNA transactions, including human basal transcriptional initiation factor TFIIE. A three-dimensional model of the TFIIE Cys4 domain is obtained by DG-based homology modeling. The role of the TFIIS Zn ribbon in the control of eukaryotic transcriptional elongation is discussed. |
| บรรณานุกรม | : |
Qian, Xiuqi , Gozani, Shai N. , Yoon, Ho Sup , Jeon, Choon Ju , Agarwal, Kan , Weiss, Michael A. . (2536). Novel zinc finger motif in the basal transcriptional machinery : three-dimensional NMR studies of the nucleic acid binding domain of transcriptional elongation factor TFIIS.
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Qian, Xiuqi , Gozani, Shai N. , Yoon, Ho Sup , Jeon, Choon Ju , Agarwal, Kan , Weiss, Michael A. . 2536. "Novel zinc finger motif in the basal transcriptional machinery : three-dimensional NMR studies of the nucleic acid binding domain of transcriptional elongation factor TFIIS".
กรุงเทพมหานคร : Nanyang Technological University, Singapore. Qian, Xiuqi , Gozani, Shai N. , Yoon, Ho Sup , Jeon, Choon Ju , Agarwal, Kan , Weiss, Michael A. . "Novel zinc finger motif in the basal transcriptional machinery : three-dimensional NMR studies of the nucleic acid binding domain of transcriptional elongation factor TFIIS."
กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2536. Print. Qian, Xiuqi , Gozani, Shai N. , Yoon, Ho Sup , Jeon, Choon Ju , Agarwal, Kan , Weiss, Michael A. . Novel zinc finger motif in the basal transcriptional machinery : three-dimensional NMR studies of the nucleic acid binding domain of transcriptional elongation factor TFIIS. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2536.
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