The cerebrovascular disease which caused hemiplegia is mostly found among neurological disease. The best way to do for the patients is conservative therapy. Patients also need to be cured continuously. Patients who are undergone disabilities have a miserable experiences of disabilities which lead to psychosocial problems. Both physical and psychosocial changes cause much stress and need some help to adapt for the normal living. Nurses as health care providers should know some influencing factors which help the patients to adapt for the well being. The researcher see the issue and feel like to study the relationship between family relationship, hope and adaptation in hemiplegic patients. The sample was selected 100 hemiplegic patients who came to clinical follow up at the Out Patient Department and Rehabilitation units in Si-riraj Hospital, Rajvithi Hospital, Ramathibodi Hospital and Prasat Neurogical Hospital. The instruments were the demographic data, the family relation, hope and adaptation questionnaries. Data were analysed by SPSS program for percentage, arithmetic means, standard deviations, Pearson product moment correlation coefficient, the hierarchical and stepwise multiple regression. The result were as follows : 1. There was a significantly positive correlation between family relation and adaptation in hemiplegic patients at the .001 level(r=.7190). 2. There was a significantly positive correlation between hope and adaptation in hemiplegic patients at the .001 (r=.6884). 3. The results of the stepwise multiple regression analysis showed that 61 percent of the variances of adaptation was accounted for by Three significant predictor, i.e. family relation, hope and Education. The results of the study bring about the recommendation that the nurse should promote the patient-family relationship. The family should be encourged to give patients tender love care as mush as hope which might enhance adaptation level and well being.