- To develop latex compound formulations for preparation of artificial bone is the aim of this research. In addition, 60% HA was selected as a base elastomeric. Three types of fillers such as styrene monomer, high styrene resin, and cassava starch were added to 60% HA latex at various contents to investigate for improvement the hardness and mechanical properties of rubber-like properties to the real bone. Casting technique was used to make an artificial bone product. It was found that the formulation used high styrene resin with cassava starch provide highest hardness and mechanical properties. Latex compound mixed with high styrene resin at the ratio of 30/70 (by weight) and cassava starch in amount of 40 gram gives high enough hardness as real bone, In addition, tensile strength, impact resistance, flexural strength obtained at this ratio is higher than others. However, artificial bone made from latex provide lower all properties than from STR 5L. Moreover, the obtained product from latex get brittle properties and can fracture easily as needed which is benefit for medicine student to study bone connected.